Madruzzo is a surname of the Trentino-Tyrolese nobility taken from the Madruzzo Castle of Madruzzo, in the Valle dei Laghi, adopted by two distinct families who had the lordship. One recognized as a progenitor a Gumpone, signer of two documents one dated 1159 and the other 1160, who held the possession of Madruzzo until the fourteenth century, when his branch died out. The second family died out in 1658, was a branch of the lords of Denno and Nanno, had a Cristoforo as progenitor, in addition to the territories of Madruzzo they had jurisdiction with baronial title of the vicariates of Val Lagarina and the county of Challant.